Alpha-1 affects multiple organs
Tortora GJ, Derrickson B. The cardiovascular system: the blood. In: Principles of Anatomy and Physiology. 12th ed. Hoboken, NJ: John Wiley & Sons, Inc. 2009: 689-716.
A decrease in A1AT serum levels increases the risk of emphysema
Using augmentation therapy to consistently correct the alpha-1-antitrypsin (A1AT) deficiency in patients with A1AT may arrest disease progression and further damage.