Alpha-1-antitrypsin (A1AT) deficiency (also known as alpha-1) is a genetic disease that leads to a decrease in circulating levels of A1AT.
Alpha-1 affects multiple organs
The presentation of alpha-1 mediated liver disease can range from chronic hepatitis to cirrhosis to, in rare cases, fulminant hepatic failure.
Alpha-1 is the major known genetic riskfactor for COPD
Alpha-1-antitrypsin (A1AT) deficiency is a genetic disease defined by decreased plasma levels of A1AT.